The invention discloses a novel guidance optical cable and a manufacturing method thereof. Acrylate is adopted as a coating material, PHB/PET liquid crystalline copolyester serves as an outer protection layer material, and an extrusion process is adopted to manufacture a guidance optical cable. Compared with the traditional guidance optical cable, the guidance optical cable of the invention has the advantages that the diameter is small, the loss is low, the micro-bending performance is good, the mechanical performance is excellent, the one-time cabling length is long (10km to 26km), the storage time is long, the manufacturing process is simple, and the use temperature range is wide.