The invention discloses a medicine used for treating infantile jaundice caused by damp pathogen retention and liver and spleen inharmony. The medicine is mainly prepared from the following raw materials in parts by weight: 2-4 parts of natural indigo, 8-10 parts of root of Sinkiang arnebia, 8-10 parts of malt, 12-18 parts of virgate wormwood herb, 8-10 parts of herb of christina loosestrife, 5-7 parts of cucumis melo, 2-4 parts of ricepaperplant pith, 5-7 parts of cape jasmine fruit, 2-4 parts of amur corktree bark, 12-18 parts of Danshen root, 5-7 parts of plantain seed, 2-4 parts of liquorice root and 5-7 parts of turmeric root-tuber. The medicine has the characteristic of scientific compatibility of 13 natural traditional Chinese medicines, is simple in formula, has the effects of invigorating the spleen to eliminate dampness and promoting bile flow to remove jaundice through synergy of the active pharmaceutical ingredients, takes effect quickly, treats both symptoms and root causes, does not have toxic or side effect, is simple in preparation method, is convenient to take, is low in cost and has an effective rate over 95%.