The invention discloses a method for preparing a drug sustained-release coating by vacuum cold spray coating technology. According to the method, the prepared medicine or bioactive factor loaded composite powder is sprayed onto the surface of a roughly treated medical material by vacuum cold spray coating technology. Due to the fact that the material prepared by the method can effectively control releasing of the medicine or a bioactive factor, the phenomenon of burst-releasing is avoided. Due to the fact that the vacuum cold spray coating technology adopted by the method can be operated at the room temperature, temperature sensitive materials, such as the medicine or the bioactive factor, are prevented from being decomposed or deactivated, and the organization structure and the physical and chemical performance of original powder can be effectively maintained. Meanwhile, the biostability of the coating is good, the powder is easy to reclaim, and the operation is simple and convenient to perform.