A method for preventing interference between a transmission control unit (TCU) and an electronic stability program (ESP). The method comprises: a splitting step: split signals of an ESP and a traction control system (TCS), so that the TCU can learn whether the TCS is in a control state; and a detection and control step: the TCU independently detects split signals of the ESP and the TCS, and when detecting that the TCS is in the control state, the TCU suspends actively sending a torque decrease request of the TCU to the ECU. In this way, mutual interference between a TCU and a TCS is avoided, and problems of vehicle jitter, vehicle locking, excessively rapid vehicle-speed decreasing, and excessively rapid hardware damage of a clutch are resolved.