The present invention relates to a binding molecule having a hepatitis B virus neutralising action by binding to at least one member selected from the group consisting of hepatitis B virus surface antigen (HBsAg) subtypes adw, adr, ayw and ayr. The binding molecule of the present invention is highly useful in the prevention and treatment of hepatitis B since the binding molecule has an outstanding ability to bind to HBsAg and so can bind to all of the four main subtypes of HBV namely adw, adr, ayw and ayr and exhibits an effect in neutralising same, and exhibits a widespread neutralising effect extending to various mutant antigens of HBsAg.