The invention discloses a preparation method of a ginkgo ginseng health care wine. According to the preparation method, 80 to 100 parts of ginkgo nut pulp, 15 to 20 parts of ginseng, 25 to 30 parts of liquorice, and 10 to 20 parts of mint are sliced into slices or smashed into powder, and an obtained mixture is delivered into a container; 15 to 20 parts of honey, and 500 to 1000 parts of baijiu with alcohol by volume ranging from 38 to 45 are added into the container; the container is sealed for dipping, and an obtained mixed material in the container is stirred for one time every 1 to 2 days; and after 30 days, herb residue is removed via filtering, and an obtained product is allowed to stand for 10 to 20 days at -10 DEG C, and is filtered so as to obtain a finished product. The preparation method is simple; economic benefit is excellent; health care efficacy of ginkgo can be achieved completely; and health care effect is obvious after long term of consumption.