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CN105283201B 靶向剂抗体偶联物及其用途 有权 转让

靶向剂抗体偶联物及其用途
摘要：
本文提供了用于包含一个或多个非天然氨基酸的双特异性抗体的方法、组合物和用途。该双特异性抗体可与一种或多种细胞上的两种或更多种不同的受体、共受体、抗原或细胞标志物结合。该双特异性抗体可用来治疗疾病或病况(例如，癌症、自身免疫病、病原体感染、炎性疾病)。该双特异性抗体可用来调节(例如，刺激或抑制)免疫应答。
摘要（英）：

Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.

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