The invention discloses a deep-second-degree burn wound high-speed rotating eschar excision device, which comprises a cutter head, wherein the cutter head is connected with a rotating power source through a transmission mechanism; a vibration mechanism is arranged in the middle of the transmission mechanism; the cutter head comprises a cutter frame; and a plurality of cutters used for eschar excision are arranged on the cutter frame. The deep-second-degree burn wound high-speed rotating eschar excision device has the beneficial effects that a cutter adopts a bent wedge-shaped structure and is provided with an elastic element, so that the telescopic flexibility of the cutting is realized; the change of an eschar excision load in a certain range can be borne; the stress condition is improved; when the preset load upper limit is exceeded, the automatic retraction is realized; the occurrence of medical accidents due to excessive excision on the burn wound part is avoided; by arranging a negative pressure adsorption tube, the collection of cut eschar fragments is realized; cut eschar fragments are prevented from falling into the device or other space positions; and the use neatness of the device is ensured. The whole device has the advantages that the structure is compact; the medical effect is good; the anti-contamination capability is high; and the portability is realized.