The invention discloses an automobile safe driving pre-warning system which comprises a controller ECU which is connected with an engine rotation speed sensor, two pressure-sensitive sensors, a timer, a yaw angular speed sensor, an automobile speed sensor, a warning device and a brake control device. The two pressure-sensitive sensors are installed on the two sides of a steering wheel respectively. The two pressure-sensitive sensors are installed on the two sides of the steering wheel respectively to detect whether a driver operates the steering wheel with one hand or without hands in the running process of an automobile. Timely pre-warning is conducted through three vibration elements and an acousto-optic alarming module, the driver is reminded to drive safely, and if a warning effect can not be achieved, the brake control device is started to decelerate the automobile forcibly.