A drive system for a surgical instrument is disclosed. The system can comprise a drive assembly, a first output assembly, and a second output assembly. The drive assembly can be coupled to a motor, and can operably transmit a force from the motor to the first output assembly and/or the second output assembly. The drive system can further comprise a shifter assembly, which can shift engagement of the drive assembly between the first output assembly and the second output assembly. A spring-loaded latch for releasably securing a drive member of n handle to a drive member socket of a coupling arrangement in a surgical end effector is also disclosed.