The invention provides an antithrombotic vascular stent and a preparation method and application thereof. An artificial blood vessel is coated with a liquid medicine carrying gel coat formed with alumina hydrogel being a coat matrix which bears antithrombotic medicine, and then the antithrombotic vascular stent is obtained. In the stent, the liquid medicine carrying gel coat can carry the antithrombotic medicine; due to the characteristics of non-degradation and slow absorption by a human body of alumina hydrogel, the medicine is gathered on the inner wall of the stent all the time, proteinosis is prevented, the antithrombotic effect is lasting, thrombi can be prevented from forming on the portion where the stent is placed or blood vessels are replaced, and the defects of an existing medicine carrying stent can be overcome fundamentally; delayed vascular restenosis or even reobstruction due to degradation of the matrix will not be caused.