The invention relates to a spinning mechanism displacement device for large-scale electrostatic spinning. The spinning mechanism displacement device comprises a spinning area supporting table, a supporting table connection plate, a height adjustment rocking handle, a spinning area transverse movement rail, a height adjustment ball screw pair, a spinning area, a transverse displacement ball screw pair, a transverse displacement servo motor, a spinning area height adjustment rail, a height adjustment connection rod and a displacement plate. One side of the displacement plate is connected with the spinning area transverse movement rail in a sliding mode, and the spinning area height adjustment rail is arranged on the other side of the displacement plate. The spinning transverse movement rail is arranged on a rail installation plate. The transverse displacement ball screw pair transversely penetrates through connection hoops arranged on the opposite faces of the rail installation plate and the displacement plate. One end of the transverse displacement ball screw pair is fixed to a connection hoop arranged on the rail instillation plate, and the other end of the transverse displacement ball screw pair is connected with the servo motor. The upper end of the spinning area supporting table is connected with the spinning area, and the lower end of the spinning area supporting table is located at one end of the supporting table connection plate. The other end of the supporting table connection plate is fixed to the displacement plate. By means of the spinning mechanism displacement device, displacement of a spinning mechanism in electrostatic spinning is achieved.