The invention discloses an ultrasonic self-cleaning anti-scaling ball valve. The ball valve comprises a valve body, a valve deck, a ball body, a valve rod and a valve rod driving mechanism. The valve body is provided with a valve body flow channel and a valve cavity located on the valve body flow channel. The ball body is rotationally arranged in the valve cavity. The valve rod is rotationally arranged on the valve body. The inner end of the valve rod stretches into the valve cavity and is matched with the ball body in a linked mode. The outer end of the valve rod is matched with the valve rod driving mechanism in a linked mode. A plurality of transducers are arranged on the outer sidewall, corresponding to the position of the valve cavity, of the valve body. The ultrasonic self-cleaning anti-scaling ball valve further comprises an ultrasonic generator. The transducers are connected with the ultrasonic generator through transducer connecting pipes. The ultrasonic self-cleaning anti-scaling ball valve has the advantage of being capable of preventing the valve cavity from scaling, thereby improving the rotation flexibility and airtightness of the ball body.