The invention discloses a full-automatic working condition generation method and device used for wind turbine generator load calculation. The method includes the following steps that firstly, a middle parameter and a wind model parameter are calculated; secondly, a basic Bladed model file is selected, and a constant value parameter in the wind model parameter and the middle parameter is substituted; thirdly, according to a variable in the basic Bladed model file, a series of working condition variable value sets are generated; fourthly, new Bladed model file data are generated for each working condition variable value set with the basic Bladed model file as a template; fifthly, the data are saved according to specified routes and working condition file names. The device comprises a middle parameter and wind model parameter generation module, a model file import module, a working condition variable value set circulating generation module, a variable searching and modifying module and a working condition file saving module. By means of the method and device, the working condition setting process is simplified, working conditions are generated full automatically, operation is easy and quick, reliability is good, and accuracy is high.