The invention relates to a two-dimensional code locking control method based on combination of synchronous-asynchronous secret key verification. The two-dimensional code locking control method based on the combination of synchronous-asynchronous secret key verification comprises locking control equipment and unlocking equipment. Two-dimensional code locking control steps are as follows: the unlocking equipment is initialized, a public and private secret key pair Pub and Pri, a synchronous password A2 and an asynchronous password B2 are randomly produced, the private key Pri and the synchronous password A2 are stored, the public key Pub, the synchronous password A2 and the asynchronous password B2 are transmitted to the locking control equipment to be stored for replacing the original public key Pub, a synchronous secrete key A1 and an asynchronous password B1; during unlocking, the unlocking equipment randomly produces the asynchronous password B2, encryption is carried out on the synchronous password B2 and the synchronous password A2 with the private key Pri, so as to generate two-dimensional code picture data, and the two-dimensional code picture data is transmitted to the locking control equipment; and the locking control equipment is decrypted by adopting the public key Pub, the synchronous password A2 and the asynchronous password B2 transmitted by the unlocking equipment are acquired, the synchronous password and the asynchronous password are verified, when A2 is equal to A1 and B2 is not equal to B1, verification is successful, equipment is successfully unlocked, and B2 and B1 are replaced.