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发明公开
CN105353135A 阿尔茨海默病标志物的用途 无效 - 驳回

阿尔茨海默病标志物的用途
摘要：
本发明公开了用于测定阿尔茨海默病(Alzheimer’s Disease，AD)标志物的试剂在制备检测受试对象患有阿尔茨海默病的试剂盒中的用途，其阿尔茨海默病标志物为IL-12(P40)，IL-12(P70)，VEGF，sCD40L，GRO，IL-7中的至少一种，为阿尔茨海默病的诊断或鉴别诊断提供了新的血液标志物；本发明还公开了联合检测VEGF和sCD40L标志物的试剂盒，尤其针对老年患者具有使用方便，无侵入性及检测成本低等特点，可直接进行外周血检测，无需采集脑脊液，减轻病人取样痛苦，而且试剂盒特异性好和敏感度高，具有良好的临床诊断价值，为实现AD的血液学诊断奠定了基础。
摘要（英）：

The invention discloses a use of a reagent for measuring an Alzheimer's disease (AD) marker in preparation of a kit for detecting a tested object suffering from Alzheimer's disease, wherein the Alzheimer's disease marker is at least one of IL-12 (P40), IL-12 (P70), VEGF, sCD40L, GRO and IL-7, and a new blood marker is provided for diagnosis or differential diagnosis of Alzheimer's disease. The invention also provides the kit for combined detection of the VEGF marker and the sCD40L marker; especially for senile patients, the kit is convenient to use, has the characteristics of no invassiveness and low test cost, can directly perform peripheral blood tests, has no need of collection of cerebrospinal fluid, relieves patient sampling pain, also has the advantages of good specificity, high sensitivity and good clinical diagnostic value, and lays a foundation for realization of hematology diagnosis of AD.

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