The invention discloses an easy-to-take circuit board clamping device, belonging to a PCB (Printed Circuit Board) clamping device in the technical field of circuit board machining equipment. The invention aims to provide an easy-to-take circuit board clamping device convenient to take for improving the clamping stability of a PCB. According to the technical solution, the device comprises a bottom clamping mechanism for clamping a PCB from the horizontal direction, an upright post connected with the bottom clamping mechanism is arranged on each of the left and right sides of the bottom clamping mechanism, the top of each upright post is connected with an ejector rod, each upright post is provided with a guiding groove, a movable clamping mechanism for clamping the PCB from the vertical direction is arranged between the upright posts, the movable clamping mechanism is positioned between the bottom clamping mechanism and the ejector rods, and the two ends of the movable clamping mechanism are clamped into the guiding grooves and move in the length direction of the guiding grooves. The easy-to-take circuit board clamping device is suitable for clamping a PCB.