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发明公开
CN105363069A 一种FeCl3调控的智能型多肽水凝胶、制备方法及其应用 失效 - 权利终止

一种FeCl3调控的智能型多肽水凝胶、制备方法及其应用
摘要：
本发明公开了一种FeCl3调控的智能型多肽水凝胶、制备方法及其应用，其是选用结构式为NH2-VdopaVKVKVK-VDPPT-KVKVKVKV-NH2的多肽在pH为9～10的Tris-HCl溶液中自组装形成的，所得水凝胶在FeCl3的作用下可坍塌为液态，本发明制备得到的水凝胶可以作为细胞培养支架。本发明提出的多肽分子自组装形成的水凝胶，可通过Fe3+的加入，使其坍塌为溶液状态，是一种Fe3+调控的智能型水凝胶，是一类较为理想的纳米组织工程材料，对人类生命健康具有重要意义。
摘要（英）：

The invention discloses FeCl3-regulated intelligent polypeptide hydrogel and a preparation method and application thereof. The preparation method includes: the FeCl3-regulated intelligent polypeptide hydrogel is formed by polypeptides, with the structural formula being NH2-VdopaVKVKVK-VDPPT-KVKVKVKV-NH2, self-assembling in a Tris-HCl solution with the pH being 9-10. The prepared hydrogel can be collapsed into a liquid state under the effect of FeCl3 and can be used as a cell culture scaffold. The Fe<3+>-regulated intelligent hydrogel which is formed by the self-assembling of polypeptide molecules can be collapsed into a liquid state by adding Fe<3+>, is ideal nano tissue engineering material and is significant to human life health.

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