The invention discloses an industrialized culture device, which is designed for the industrialized production of tissue engineering skin, wherein the industrialized culture device is composed of a controllable gas phase system, a liquid phase system, a simulation vibration frequency platform and a program-variable control platform. Tissue engineering product production and test devices are rare in variety in the market; for a targeted solution, no ideal device can achieve matching with and joint to the industrialized production; and on the basis of the bottleneck problems such as requirements on the complexity of tissue engineering skin culture conditions, the variability of culture modes and seamless joint to industrialization, the industrialized culture device for biological reaction of tissue engineering skin disclosed by the invention is designed and researched in order to solve the actual problems.