The invention discloses a line loss reactive voltage comprehensive management method. The method comprises an automatic power supplementing step, and an abnormal data checking step. The automatic power supplementing step specifically comprises substeps of determining deficiency quantity of power; if the deficiency quantity of the power is one, acquiring 24 hours of power and opposite side power, and determining whether the acquired 24 hours of power and the opposite side power are complete; if the acquired 24 hours of power is complete, computing forward active power and reverse active power, so as to finish power supplementation; and verifying the finished supplemented power. The quality of extracted data is analyzed based on an internal cleaning rule, and absent or wrong data is identified automatically and is automatically repaired according to a corresponding rule. Labor workload is greatly reduced, line loss rate accuracy is improved, and application level of reactive voltage management is improved, so that the line loss management level of a power grid enterprise is improved.