The invention relates to a process of printing and dyeing animal skin with brassica juncea juice. The process includes the following steps: a) preparing a brassica juncea dye; b) preparing a dye; c) treating animal skin; d) dyeing the animal skin; e) hot-steaming the animal skin; and f) after-finishing the animal skin. The process can improve adhesion force of the vegetable dye on the animal skin, so that the printed and dyed artificial leather is not liable to discolor and fade.