The invention discloses a sealing cylinder base-type fuse pressure release mechanism, which comprises a sealing cylinder base, a sealing ring and a fuse carrier, wherein the fuse carrier comprises a floating end cover, a support, a handle, an insulated arm, a connection rod, a signal device and a wire holder; the sealing cylinder base has a cylindrical structure with an opening in the single direction; the floating end cover is arranged at the opening end of the sealing cylinder base; the sealing ring is arranged between the floating end cover and the sealing cylinder base; the support is arranged at the front end of the floating end cover; the support is connected with the floating end cover; a compression spring is arranged between the support and the floating end cover; the handle is located at the front end of the support; and the handle is connected with the support. According to the pressure release mechanism of the invention, a pressure release function is provided, one part of pressure can be released when pressure in the sealing cylinder base is over large, over large pressure in the sealing cylinder base to result in ejection of the fuse carrier can be prevented, the operation is convenient, and the sealing is reliable.