The invention provides a self-help turnover guardrail and mattress and a using method thereof and belongs to the field of rehabilitation nursing instruments. The self-help turnover guardrail and mattress are provided with multiple detachable connectors and ground supports which are matched with a bed to be used and are all easy to mount and detach, lateral supporting guardrail structures used for closing and having reliable strength are arranged, and friction force is reduced by a smooth air-permeable thin-film mattress. A person lying in bed can have a self-help supporting point at will by using the closed guardrail and achieve self-help body slippage and turnover on the bed provided with the guardrail and mattress with the self-help arm power and torque by means of the smooth thin-film surface and coupled with self-coordination. The person lying in bed overcomes the difficulty that the person lying on a sickbed having a turnover function cannot move the body or turn over by himself/herself. The using method is applicable to the situation that the person lying in bed performs self-help turnover at different positions on the matched bed, and self-help turnover is achieved correctly. The self-help turnover guardrail and mattress are simple in structure, easy to make and convenient to dismount and use. The person lying in bed can achieve self-help turnover by means of the self-help turnover guardrail and mattress and the using method thereof, and the auxiliary nursing work amount of auxiliary nursing workers is reduced.