The invention belongs to the technical field of transformation of low-permeability reservoirs of oil and gas fields, is used for a transformation process of repeated fracturing of a horizontal well of an oil well, and in particular relates to a compression type double-sealing and single-clamping subsection fracturing process pipe column. The compression type double-sealing and single-clamping subsection fracturing process pipe column is sequentially connected with a hydraulic type safety connector, a reverse circulation valve, a KDB type hydraulic anchor, an upper packer, a sand blower and a lower packer through screw threads from top to bottom; the upper packer and the lower packer are Y-type mechanical compression type packers. According to the compression type double-sealing and single-clamping subsection fracturing process pipe column and a fracturing method thereof, provided by the invention, the two Y-type mechanical packers are used for packing a transformed layer section, the setting of the packers is not influenced by the change of the injection and discharging amounts of a construction pump, and the unpacking of the packers is not influenced by a mined-out negative-pressure phenomenon; working pipe columns can be dragged to change positions for a plurality of times so as to be subjected to sealing and clamping construction, and furthermore, the limitation caused by applying a conventional K344 type double-sealing and single-clamping subsection fracturing process pipe column to repeated transformation of the horizontal well of the low-permeability oil well can be effectively solved.