The invention relates to a structure for controlling a vehicle wheel to rotate or stop, in particular to a control structure of locking and releasing a vehicle wheel. The structure comprises a hub, a rotating disk, an adjusting knob and a driving unit. Two sides of accommodation space inside the hub are provided with central holes which are communicated to the outside. One or more locking grooves is/are arranged in the outer side surface of a central hole on one side. The driving device is arranged in the accommodation space and utilized to drive the rotating disk. A key groove is arranged in the outer side surface of the rotating disk in order to rotatably align at all locking grooves and internally and movably provided with a sliding key. The center of the rotating disk is provided with an axle arranged in the outside of the hub in a penetrating mode and further provided with a rotary knob used for assembling the adjusting knob. The inner side surface of the rotary knob is provided with a guide means for driving the sliding key to slip. Locking or releasing state is formed in such a manner that a linkage sliding key slips to the hub and the locking groove of the rotating disk such that the hub and a pre-set vehicle tire can be easily switched in order to drive by the driving unit or in a manually-operated mode. Therefore, the purpose of bringing convenience to move the pre-set vehicle by hands is fulfilled.