The invention belongs to the technical field of resonators, and particularly relates to a thermistor piezoelectric quartz crystal resonator and a manufacturing process thereof. The thermistor piezoelectric quartz crystal resonator comprises a piezoelectric quartz crystal resonator and a substrate, wherein the substrate comprises contact blades, thermistors and insulation paste; the thermistors are electrically connected with the contact blades; the insulation paste is used for encapsulating the thermistors on the contact blades; and the contact blades wrap the surface of the insulation paste. The manufacturing process of the thermistor piezoelectric quartz crystal resonator comprises the following steps: forming a contact blade framework by stamping or etching or liquid metal forming; bonding the contact blades on the contact blade framework to the contact blades through a conductive connection substance; encapsulating the thermistors on the contact blades by filling the insulation paste; partitioning the contact blades out, and performing bending to form the substrate; and lastly, connecting the substrate with the piezoelectric quartz crystal resonator through the conductive connection substance to form a thermistor piezoelectric quartz crystal resonator structure. The thermistor piezoelectric quartz crystal resonator is simple in structure, low in cost and stable in performance.