The invention discloses an agricultural seeding machine provided with an anti-shake seed premixing mechanism and belongs to the field of automatic equipment of agricultural farming machinery. The agricultural seeding machine is characterized by further comprising a sowing mechanism, wherein the sowing mechanism comprises a seed bin, a powder bin, a mixing bin, a seed separating device and a sowing wheel, the seed bin and the powder bin are communicated with the mixing bin through a guide pipe, and the mixing bin is connected with the sowing wheel through the seed separating device; the mixing bin is in a hollow spherical shape, and a spiral mixing strip hole is formed in the mixing bin. Seeds and medicinal powder falling from the seed bin and the powder bin enter the rotating mixing bin, are rolled and mixed under the guidance of the spiral mixing strip hole and are finally sufficiently and uniformly stirred and mixed. The mixing movement path of the seeds and the powder is lengthened due to arrangement of the spiral mixing strip hole, and the seeds and the powder are more uniformly mixed.