The invention discloses an anti-theft screw. The anti-theft screw comprises a screw body and an unlocking key, wherein the screw body comprises a screw head and a screw rod, the screw head is fixedly connected to one end of the screw rod, a groove is formed in one end, which is far from the screw rod, of the screw head, concave-convex groove threads are formed in the groove, the shape of the cross section of the unlocking key is the same as that of the concave-convex groove threads, and the unlocking key is matched with the concave-convex groove threads. In the mode, the anti-theft screw has the advantages of novel structure, simplicity and convenience in operation, convenience in installation and removal, time saving, labor saving, safety, theft prevention, firmness in fixing, stable performance, reliability, long service life, convenience, practicability and the like and has a broad market prospect in popularization of the anti-theft screw.