The invention relates to a vacuum tube bundle drying machine. A feed port is formed in one side of the tube bundle drying machine, and a discharge port is formed in the other side; a waste steam outlet is formed in a shell of the tube bundle drying machine; rotating shafts at two ends of a tube bundle of the tube bundle drying machine are movably connected with the shell through mechanical seals; one ends of the rotating shafts are connected with transmission devices; the rotating shafts are hollow shafts, and inner cavities thereof are communicated with the tube bundle of the tube bundle drying machine; the rotating shaft on one side of the discharge port of the tube bundle drying machine is communicated with a steam intake device; the rotating shaft on one side of the feed port of the tube bundle drying machine is communicated with a condensed water drainage device; the feed port of the tube bundle drying machine is communicated with a feeding device; the discharge port of the tube bundle drying machine is communicated with a discharge device; and a waste steam outlet of the tube bundle drying machine is communicated with a waste steam treatment device. The vacuum tube bundle drying machine is simple in structure, convenient for use, low in manufacturing cost and wide in application range, can preferably reduce the steam temperature needed by material drying, reduces the energy consumption, reduces the waste steam emission, and achieves the purposes of energy conservation and emission reduction.