The invention provides an oil reservoir prediction method based on a spatial amplitude change rate of bright spots. Firstly, whether a target interval of a research region meets the conditions of oil reservoir searching by a bright spot technology is analyzed and judged from a plurality of aspects; and then the change characteristics of seismic reflection amplitudes within and out of an oil reservoir height are analyzed along three different directions in a lithologic trap to be evaluated which has a bright spot characteristic, and if the amplitude changes respectively show a two-segment characteristic that: amplitude data within the oil reservoir height is the first segment, the slope is relatively small, and the amplitude is relatively large; and the amplitude data out of the oil reservoir height is the other segment, the amplitude is obviously lower than that of the first segment, and an inflection point, at which the amplitude suddenly reduces, exist between the first segment and the second segment, then the oil possibility of the trap is relatively large. By analyzing the amplitude change rates in different direction of the lithologic trap which shows bright spots in seismic reflection, the oil possibility of the trap is predicted, and the precision of oil reservoir prediction by utilizing the bright spot characteristic is improved.