The invention discloses systems and methods for non-serial, substantially simultaneous or simultaneous tissue sampling and placement of multiple markers/fiducials in a non-linear, distributed or three dimensional configuration. The systems and methods can be applicable to other forms and combinations of distributed/3 dimensional/spherical localization which may include a single procedure or combination of procedures that may include 3D biopsy, fiducial placement, brachyiherapy seed placement, injection/infusion of bioactive materials (e.g., chemotherapy, small molecules, cellular materials, cells, caustic materials, proteolytics, embolic material, glue, etc.), thermally or electrically derived ablation.