A system and method to treat neural communication impairment is provided. The neural communication impairment is present in a neural pathway, which can be a cortico-neuromuscular pathway, an intra-brain neural pathway, or in a sensory-cortico pathway. A synchronized external stimulation is applied to a first point in proximity to a first neural component at one end of the neural pathway and to a second point in proximity to a second neural component at the other end of the neural pathway. Two induced neural handshake signals contemporaneously arrive at a neural communication impairment point in the neural pathway, triggering and stimulating a rehabilitation process by which the neural connection is permanently improved. The synchronized applied electrical signals applied to the first and second points may have an opposite polarity in dipolar neural stimulation, or may have identical polarity and waveform in in-phase neural stimulation.