The invention relates to the field of washing powder equipment, in particular to a cyclone dust removal device for the washing powder production process. The cyclone dust removal device comprises an exhaust pipe, an air inlet pipe and a top cover, a cylindrical barrel is connected to the top cover, the exhaust pipe is arranged in the cylindrical barrel and connected with the top cover, the air inlet pipe is arranged on the side face of the cylindrical barrel, and the exhaust pipe is wound with a spiral guide blade; a straight-line guide blade is connected to the lower end of the exhaust pipe, an inversed circular cone is arranged at the lower end of the straight-line guide blade, and a circular cone is connected to the lower end of the cylindrical barrel; an air flow enters the dust removal device from the air inlet pipe, the straight-line motion of the air flow is converted into spiral and downward circling motion under action of the spiral guide blade, air containing dust generates large centrifugal force in the rotating process, and dust is separated from the air flow to be thrown to the wall of the equipment; and when the air flow moves to the position close to the bottom face of the inversed circular cone, backspin air flow cannot continuously spin downwards, helical motion of the air flow is converted into straight-line motion under action of the straight-line guide blade, the air flow is exhaust from the exhaust pipe, and the dust removal efficiency is high.