The invention provides a method for realizing digital-analog hybrid simulation of a power system of a thermal power plant. The method comprises the following steps: (1) a digital model power generator in a power system simulation platform sends a simulation amount to the power system of the thermal power plant; and (2) the power system of the thermal power plant sends mechanical power of a steam turbine to the digital model power generator in the power system simulation platform so as to realize real-time closed-loop digital-analog hybrid simulation. According to the method, the modeling is performed by applying a two-phase flow process, systems such as a boiler system, a steam turbine system, an electric system, a control and protection system and the like are truly simulated, and the gas-liquid two-phase process of the thermal power plant is accurately simulated, so that the capability and precision of long-term modeling in a power system of a thermal power plant in an existing digital-analog hybrid simulation technology are improved and the problem in real-time simulation of access of large-scale power grids to the power system of the thermal power plant is solved.