The invention discloses a novel machine case with an anti-theft alarm function, and relates to the field of machine cases. The novel machine case comprises a front panel, a rear panel, a case body, a safety door, a pull rod, a button switch, an electronic cipher, two vibration sensors, four door magnetic sensors, an alarm apparatus, two electronic locks, a mechanical lock, two rotating shafts, two small hinges, two large hinges, an access controller, a storage battery, a measurement and control processor, two USB interfaces, 12 measurement and control interfaces, two power interfaces and six fans. Through designing an integrated anti-theft alarm system, the safety performance of the machine case is greatly improved; the problem of high integration level of the machine case in a spatial limitation condition, the problem of high heat consumption of the machine case and the problem that the machine is difficult to maintain are solved; and the novel machine case can be widely applied to products of aerospace telemetry, remote control, high-bit rate data transmission, recorders, ground detection and the like.