The invention provides a cerebrum resonance data process system, massage device and method based on audio control. By processing the audio, the sound volume changes periodically the massage device can generate different vibrations being synchronous with the change of the sound volume to stimulate the cerebrum, and enhance the brain wave; specific frequency is employed to make a related position of the cerebrum generate resonance, the brain wave signal is amplified to activate the position, of the body, which needs to be stimulated and massaged, and therefore the effect of treating corresponding positions is achieved, affected parts can be treated, brain fatigue can also be eliminated, the cerebrum resonance data process system, massage device and method have great benefit to the cerebrum.