A drug composition with an anti-anoxia effect is characterized by being prepared from astragaloside, a tanshinone extract, a B Salvianolic acid extract, total ginsenoside ginseng root and rhizoma polygonati steroid saponin. Proved by pharmacology tests, the composition has stronger anti-hypoxic activity than the single ginsenoside, the single B Salvianolic acid extract, the single tanshinone extract, the single astragaloside and a single rhizoma polygonati steroid saponin extract, and the synergistic effect of chemical components of a traditional Chinese medicine is embodied. The drug composition can be made into oral preparations such as a granula, a tablet and soft sweets.