The invention discloses a medicine with efficacies of losing weight and burning fat. The medicine is mainly prepared from the following raw materials in parts by weight: 15-25 parts of poria cocos, 5-15 parts of cassia twig, 5-15 parts of honey-fried licorice roots, 5-15 parts of rhizoma zingiberis, 5-15 parts of red ginseng tails, 25-35 parts of ginger, 5-15 parts of rhizoma atractylodis macrocephalae, 5-15 parts of herba ephedra, 10-20 parts of dragon bones, 10-20 parts of oyster, 18-22 parts of rhizoma alismatis, 8-12 parts of radix stephaniae tetrandrae, 8-12 parts of hawthorn, 8-12 parts of rheum officinale and 12-18 parts of lotus leaves. According to the medicine with the efficacies of losing weight and burning fat, 15 natural traditional Chinese medicines are selected for scientific combination; the formula is simple; various raw materials work together to achieve the efficacies of enriching blood, benefiting qi, expelling toxin and burning fat; the medicine is fast in acting, free of a toxic or side effect, simple in preparation method, convenient to take and low in cost and is capable of treating both symptoms and root causes; and the effective rate reaches 97% or over.