The invention provides a method for efficiently removing antibiotic residues in livestock manure through normal-temperature fermentation. The method includes the following steps that 1, concentrated sulfuric acid with the mass ratio of 1%-3% is added into the livestock manure, and acid regulating treatment is carried out for 1-2 hours; 2, pH is adjusted to range from 4.5 to 6.0; 3, the treated manure is spread to a sealed or semi-sealed container, the temperature is controlled to range from 28 DEG C to 35 DEG C, and solid state fermentation is carried out for 4-6 days. A light source is arranged in a fermenting container for illumination cultivation, and wood shavings are added into the livestock manure, so that degradation of antibiotics is accelerated. The antibiotic pollutants can be any one of tetracycline antibiotics, sulfonamide antibiotics and fluoroquinolone antibiotics or a mixture of several of tetracycline antibiotics, sulfonamide antibiotics and fluoroquinolone antibiotics, and the method is particularly suitable for removing tetracycline antibiotics and sulfonamide antibiotics. Compared with an existing technology for removing antibiotics in the livestock manure, it can be achieved that the content of the antibiotics in the livestock manure is reduced in a short time under the normal temperature condition, and the method does not depend on the high temperature condition.