The invention discloses a nuclear power plant equipment fault early warning analysis method and system based on a dynamic simulation model. The system comprises a nuclear power station real-time/historical database which is used for providing basic parameters needed by the dynamic simulation model during normal operation; the dynamic simulation model built based on a nuclear power station total range analog machine, wherein the dynamic simulation model is used for providing reference parameter values of all monitoring equipment; a real-time data collection center which is used for measuring the real-time operation parameter values of all monitoring equipment; and a dynamic early-warning analysis platform which is used for inputting the real-time operation parameter values of all monitoring equipment and the corresponding reference parameter values into a trend early-warning model, carrying out the dynamic early-warning analysis of all monitoring equipment through employing a comprehensive early-warning analysis strategy in the trend early-warning model, and starting early-warning for the monitoring equipment which is determined to be fault equipment through the comprehensive early-warning analysis strategy. The method and system can recognize the fault equipment in a nuclear power plant in advance during operation and start early-warning, so as to prevent the fault equipment from being damaged further, thereby avoiding an accident happening to the nuclear power plant, and improving the operation efficiency of the nuclear power plant.