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发明授权
CN105523984B （1R，2S）-1-苯基-2-（1-吡咯烷基）-1-丙醇的制备方法 有权

（1R，2S）-1-苯基-2-（1-吡咯烷基）-1-丙醇的制备方法
摘要：
本发明公开了一种(1R，2S)‑1‑苯基‑2‑(1‑吡咯烷基)‑1‑丙醇的制备方法，以DL‑1‑苯基‑2‑(1‑吡咯烷基)‑1‑丙酮为起始原料，经拆分、消旋、还原三个步骤，制备(1R，2S)‑1‑苯基‑2‑(1‑吡咯烷基)‑1‑丙醇。本发明一次拆分收率在35％以上，使用的拆分剂易于回收，回收率为90％以上；消旋工艺在弱碱性条件下进行，消旋收率较高；还原得到(1R，2S)‑1‑苯基‑2‑(1‑吡咯烷基)‑1‑丙醇的收率在85％以上。本发明具有反应条件温和，工艺稳定，产品光学纯度高，成本低，生产安全性高等优点。
摘要（英）：

The invention discloses a preparation method of (1R,2S)-1-phenyl-2-(1-pyrrolidyl)-1-propanol. According to the preparation method, DL-1-phenyl-2-(1-pyrrolidyl)-1-acetone is taken as a starting material and subjected to resolution, racemization and reduction, and (1R,2S)-1-phenyl-2-(1-pyrrolidyl)-1-propanol is prepared. The yield of one-time resolution is higher than 35%, a resolving agent is easy to recover, and the recovery rate is higher than 90%; the racemization process is performed under the slightly alkaline condition, and the racemization yield is higher; the yield of (1R,2S)-1-phenyl-2-(1-pyrrolidyl)-1-propanol obtained through reduction is higher than 85%. The preparation method has the advantages of mild reaction conditions, stable process, high product optical purity, low cost, high production safety and the like.

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