The invention relates to the technical field of drug packaging, in particular to a packaging structure for an oral liquid of old people. The packaging structure for the oral liquid of old people comprises a bottle body, wherein the lower part of the bottle body is provided with a close-up opening; a flexible liquid outlet tube is connected below the close-up opening; sealing paper I is arranged at a joint of the liquid outlet tube and the close-up opening; sealing paper II is arranged on the middle upper part of the bottle body; the oral liquid is arranged between the sealing paper I and the sealing paper II; the upper part of the bottle body is provided with an opening; a piston rod is arranged in the opening; the upper end of the piston rod is provided with a handle; the lower bottom surface of the piston head of the piston rod is provided with a bump for tearing the sealing paper II; a retainer ring is arranged between the handle and the upper end surface of the bottle body; and a notch is formed in the retainer ring. A drug packaging bottle with the packaging structure is convenient to open for drinking, so that the drug-use safety of old patients can be improved while the curative effect of the drugs is guaranteed.