The invention provides a distribution network simulation method of considering interaction of a main network and a distribution network. According to the method, an initial state is determined through integrated power flow calculation of the main network and the distribution network; reconstruction is carried out at the distribution network side according to simulation settings; whether the security constraint of the main network is met or not is considered in the reconstruction process; the operating state of the main network is adjusted and the distribution network reconstruction strategy is simulated again according to the security constraint of the main network until the simulation result meeting the security constraint of the main network is obtained; and the distribution network operation simulation of considering the interaction of the main network and the distribution network is achieved. According to the method provided by the invention, the supporting capacity of the main network on the distribution network can be considered when the operating state of the distribution network is simulated; and the authenticity and the accuracy of researching the interaction of the main network and the distribution network and active distribution network operation simulation are effectively improved.