The invention relates to a manufacture method of a self-cleaning fabric. The manufacture method comprises the following steps: uniformly mixing polyvinyl chloride, polyoxyethylene-polyoxypropylene block copolymer, epoxy resin, nanometer titania, towel gourd juice, nanometer mica powder and polystyrolsulfon acid, heating to a molten state, adding benzyl butyl phthalate, cellulose ester, nanometer chitin and residual components, uniformly mixing to obtain a modified spinning melt, performing spinning and postprocessing to obtain ultrafine denier fibers, and spinning the spinning fibers to obtain the self-cleaning fabric. By virtue of blending spinning of the combined materials, a hierarchical structure combining a micron structure with a nanometer structure is formed on the surface of the fabric, so that the surface roughness of the fabric is enhanced, and the self-cleaning property and the water and oil repellent performance of the fabric are improved greatly.