The invention provides an operation control method of a fluid heating road snow-melting system, and belongs to the field of operation process control of the fluid heating road snow-melting system. The problems that in the operation process of the conventional fluid heating road snow-melting system, the setting of system operation parameters is blind, and different stages of the snow-melting process cannot be effectively controlled are solved. The operation control method of the fluid heating road snow-melting system includes: determining a to-be-melted stage, a snow-melting stage, and an after-melting evaporation stage of the fluid heating road snow-melting system; establishing a fluid heating road snow-melting performance simulation evaluation system by employing a numerical simulation method; obtaining related influence factors for influencing the operation status of the fluid heating road snow-melting system; regarding the related influence factors as the operation parameters of the fluid heating road snow-melting system, bringing forward a parameter setting mode, and making a control method. According to the method, the system parameters are reasonably adjusted according to the snow-melting characteristics, the operation cost of the system is reduced, and the snow-melting effect is good.