Systems and methods for Carrier Sense Adaptive Transmission (CSAT) and related operations in unlicensed spectrum are disclosed to reduce interference between co-existing Radio Access Technologies (RATs). The parameters for a given CSAT communication scheme may be adapted dynamically based on received signals from a transceiver for a native RAT to be protected and an identification of how that RAT is utilizing a shared resource such as an unlicensed band. Other operations such as Discontinuous Reception (DRX) may be aligned with a CSAT Time Division Multiplexed (TDM) communication pattern by way of a DRX broadcast/multicast message. Different TDM communication patterns may be staggered in time across different frequencies. Channel selection for a co-existing RAT may also be configured to afford further protection to native RATs by preferring operation on secondary channels as opposed to primary channels.