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发明授权
CN105582548B 人UBA2基因的用途及其相关药物 有权 转让

人UBA2基因的用途及其相关药物
摘要：
本发明公开了人UBA2基因的用途及其相关药物。本发明公开了人UBA2基因在肿瘤治疗、肿瘤诊断及药物制备中的用途。本发明还进一步构建了人UBA2基因小分子干扰RNA、人UBA2基因干扰核酸构建体、人UBA2基因干扰慢病毒并公开了它们的用途。本发明提供的siRNA或者包含该siRNA序列的核酸构建体、慢病毒能够特异性抑制人UBA2基因的表达，尤其是慢病毒，能够高效侵染靶细胞，高效率地抑制靶细胞中UBA2基因的表达，进而抑制肿瘤细胞的生长，促进肿瘤细胞凋亡，在肿瘤治疗中具有重要意义。
摘要（英）：

The invention discloses application of a human UBA2 gene and related drugs of the human UBA2 gene. The invention discloses application of the human UBA2 gene in tumor treatment, tumor diagnosis and drug preparation. The invention further constructs human UBA2 gene small interference RNA, a human UBA2 gene interference RNA constructor and a human UBA2 gene interference lentivirus and also discloses applications of the human UBA2 gene small interference RNA, the human UBA2 gene interference RNA constructor and the human UBA2 gene interference lentivirus. The siRNA or the RNA constructor or the lentivirus containing the sequence of the siRNA provided by the invention can specifically inhibit the expression of the human UBA2 gene, and especially, the lentivirus can effectively infect a target cell and effectively inhibit the expression of UBA2 gene in the target cell, so that the growth of tumor cells is inhibited and tumor cell apoptosis is promoted; therefore, the invention is of great significance in the treatment of tumors.

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