The invention provides a liquid crystal composition. The liquid crystal composition comprises one or more compounds as shown in the general formula I-1 and/or general formula I-2; one or more compounds as shown in the general formula II; one or more compounds as shown in the general formula III; and one or more compounds as shown in the general formula IV. The liquid crystal composition has characteristics of proper optical anisotropy, proper dielectric anisotropy, high clearing point, good cryogenic storage stability, good high-temperature stability and UV stability and the like, is applicable to a liquid crystal display, can effectively reduce driving voltage and also can be applied to a harsh operating environment. The invention also discloses a liquid-crystal display device containing the liquid crystal composition.