The invention belongs to the technical field of medical equipment and provides a double-end detector-based crystal resolution chart calculation method and device. The method comprises the following steps: removing event information which is lower than a preset energy threshold in all event information collected by a double-end detector according to the preset energy threshold; obtaining a single-end crystal position coordinate of the double-end detector after the event information which is lower than the preset energy threshold is removed; and calculating a double-end crystal position coordinate of the double-end detector according to the single-end crystal position coordinate of the double-end detector to obtain a crystal resolution chart of the double-end detector. Through the double-end detector-based crystal resolution chart calculation method and device, the reliability of the crystal resolution chart calculation method is improved; and the spatial resolution performance of the double-end detector is relatively well represented.