The invention relates to the field of electrical equipment, and discloses a full-automatic box assembling and stacking system and method. The system comprises a control center and an automatic destacking unit, a radio frequency identification unit, a camera sampling unit and an automatic stacking unit which are connected with the control unit respectively; the automatic destacking unit is used for automatically disassembling a whole pile into multiple separate boxes; the radio frequency identification unit is used for reading bar code information tagged on articles in each box and sending the bar code information to the control center; the camera sampling unit is used for conducting photo-taking sampling on each box and sending sampling information to the control center; the automatic stacking unit is used for stacking the boxes into piles according to a preset rule and temporarily storing the piles; the control center is used for receiving, storing and displaying the bar code information and the sampling information and comparing the bar code information and the sampling information. According to the full-automatic box assembling and stacking system and method, the reliability is high, the manual box assembling and stacking time and the manual intervention confirmation time are saved, the automation degree is high, and the labor cost of an enterprise is reduced.